Mutations in bacterial promoters may increase or decrease the rate of gene transcription. Promoter m… Show more Mutations in bacterial promoters may increase or decrease the rate of gene transcription. Promoter mutations that increase transcription are termed up- promoter mutations, and those that decrease transcription are termed down- promoter mutations. Review the consensus sequence for the -10 box in prokaryotes. The sequence of the -10 region of the promoter for the lac operon is TATGTT. Comparing the consensus sequence with the lac promoter -10 sequence, would you expect the following mutations to be up- promoter or down- promoter mutations? A. TATGTT to TATATT B. TATGTT to TTTGTT C. TATGTT to TATGAT • Show less