Citrate competes with oxaloacetate for binding to citrate synthase. Isocitrate dehydrogenase is acti… Show more Citrate competes with oxaloacetate for binding to citrate synthase. Isocitrate dehydrogenase is activated by Ca2+ ions, which are released when muscle contracts. How do these two regulatory strategies assist the cell in making the transition from the rested state (low citric acid cycle activity) to the exercise state (high citric acid cycle activity)? • Show less